Submitted by kdorfman on Fri, 03/25/2022 - 15:34

Sodium Valproate (Fisher 11474361)

Store powder at RT

Make 100 mM stock: 0.166g in 10 mL H2O

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SKU 02152064-CF
Alternate Names 2-Propyl pentanoic acid; Valproic acid sodium salt; Sodium 2-propylpentanoate
Application Notes Sodium Valproate is reported to cause inositol depletion, activate the ERK pathway, inhibit GSK-3α and GSK-3β. Valproic Acid has been reported to be a potent inhibitor of HDAC (histone deacetylase) in vitro (IC50 = 400 μM for HDAC1), thereby relieving HDAC-dependent transcriptional repression and causes the hyperacetylation of histones in cultured cells. In animal studies, Valproic Acid has been observed to reduce tumor growth and metastasis formation. Additionally, Valproic Acid is reported to activate Wnt-dependent gene expression and to mimic trichostatin A in the inhibition of histone deacetylase. This compound is also an inhibitor of the CYP2C9 enzyme.
Base Catalog Number 152064
Biochemical Physiological Actions Anti-convulsant that also has efficacy as a mood stabilizer in bipolar disorder.
Boiling Point 219.5 deg C
CAS # 1069-66-5
Density 0.904 g/cu cm at 25 deg C
EC Number 213-961-8
Format Crystalline powder
Hazard Statements H302
Molecular Formula C8H15NaO2
Molecular Weight 166.196 g/mol
Personal Protective Equipment Dust mask , Eyeshields, Gloves
RTECS Number YV7876000
Safety Symbol GHS07
Solubility In water, 2.0X10+3 mg/L at 20 deg C
Usage Statement Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Vapor Pressure 8.47X10-2 mm Hg at 25 deg C (est)