Valproate

Sodium Valproate (Fisher 11474361)

Store powder at RT

Make 100 mM stock: 0.166g in 10 mL H2O

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SKU	02152064-CF
Alternate Names	2-Propyl pentanoic acid; Valproic acid sodium salt; Sodium 2-propylpentanoate
Application Notes	Sodium Valproate is reported to cause inositol depletion, activate the ERK pathway, inhibit GSK-3α and GSK-3β. Valproic Acid has been reported to be a potent inhibitor of HDAC (histone deacetylase) in vitro (IC50 = 400 μM for HDAC1), thereby relieving HDAC-dependent transcriptional repression and causes the hyperacetylation of histones in cultured cells. In animal studies, Valproic Acid has been observed to reduce tumor growth and metastasis formation. Additionally, Valproic Acid is reported to activate Wnt-dependent gene expression and to mimic trichostatin A in the inhibition of histone deacetylase. This compound is also an inhibitor of the CYP2C9 enzyme.
Base Catalog Number	152064
Biochemical Physiological Actions	Anti-convulsant that also has efficacy as a mood stabilizer in bipolar disorder.
Boiling Point	219.5 deg C
CAS #	1069-66-5
Density	0.904 g/cu cm at 25 deg C
EC Number	213-961-8
Format	Crystalline powder
Hazard Statements	H302
Molecular Formula	C8H15NaO2
Molecular Weight	166.196 g/mol
Personal Protective Equipment	Dust mask , Eyeshields, Gloves
RTECS Number	YV7876000
Safety Symbol	GHS07
Solubility	In water, 2.0X10+3 mg/L at 20 deg C
Usage Statement	Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Vapor Pressure	8.47X10-2 mm Hg at 25 deg C (est)