Valinomycin

Potassium Ionophore, MW: 1111.32

Sigma V0627

Insoluble in water

stock is 10 mg/mL in DMSO

• cyclododecadepsi-peptide ionophore antibiotic.
• potassium ionophore that transports K+ across biological and artificial lipid membranes.
• can induce K conductivity in cell membranes
• uncouples oxidative phosphorylation,
• induces apoptosis in murine thymocytes, and in pre-B cell.
• inhibits NGF-induced neuronal differentiation
• antagonizes ET-induced vasoconstriction.
• Useful in studies of K transport in mitochondria.