Submitted by kdorfman on Thu, 06/01/2023 - 18:38

PLK4 (Polo-like kinase) inhibitor

Plk4 has been identified as a master regulator of centriole replication, and its aberrant expression is closely associated with cancer development

PLK4 functions downstream of ROCK2 to drive centrosome amplification in arrested cells. PLK4 overexpression induces centrosome amplification and chromosome instability and causes the suppression of primary cilia formation.

100uM stock

  • use 125 nM for HeLa (2.5 uL stock in 2 mL medium)

  • use 300 nM for LLCPk-1 (6 uL stock in 2 mL medium)