Dog DNA summary

Dog DNA summary kdorfman Wed, 08/02/2023 - 14:47

Genes

letter	gene	full name	traits
E	MC1R	melanocortin 1 receptor	eumelanin (requires signal molecule from agouti or defb) vs. pheomelanin ee produces a non-functioning MC1R
K	defb103	defensin beta 103 (= CBD103 beta-defensin 103)	dominant black has a glycine deletion K^B makes a signal that binds tightly to MC1R, preventing agouti expression
B	TyRP1	tyrosinase related protein 1	black (B_) vs brown (bb)
A	ASIP	Agouti Signaling Protein	ASIP promotes pheomelanin (aa: no signal, A_ signal with varying on-off patterns)

MC1R Alleles

letter	gene	full name	traits
E
ee

Agouti Alleles

letter	gene	full name	traits
A^y
A^w
aa

NOTE: If you have the nucleotide sequence for an individual and the reference amino acid sequence, to compare them:
Blastx
Query: nucleotide sequence
Subject: reference amino acid sequence

Agouti sequences

Agouti sequences kdorfman Mon, 08/21/2023 - 14:08

ASIP

To find the crucial 82, 83, 96 amino acids:

_ _ PRPP...CVAT _
82 83 ................. 96

MC1R sequences

MC1R sequences kdorfman Mon, 08/21/2023 - 14:10

MC1R

TYRP sequences

TYRP sequences kdorfman Mon, 08/21/2023 - 14:09

TyRP

defB103

defB103 kdorfman Mon, 08/21/2023 - 14:10

defB