Vitamin D
Vitamin D kdorfman Fri, 04/22/2022 - 17:53D3-calciferol
C27H44O
MW = 384.65
Solubility (from Cayman Chemical)
| solvent | mg/mL | = mM |
|---|---|---|
| ethanol | 30 | ~78 mM |
| DMSO | 3 | ~ 7.8 mM |
| DMF | 25 | ~65 mM |
Stock solution: 29 mg/mL (~75 mM) in ethanol
General Description (from Thermo Scientific)
- Vitamin D3 is a steroid hormone generated in the skin when the 7-dehydrocholesterol interacts with ultraviolet irradiation. It can also be found in several types of food for daily intake.
- Vitamin D3 binds to vitamin D receptors, thus modulating gene expression
Applications
- In in vivo studies, vitamin D3 has been implicated in the maintenance of blood calcium and phosphorus levels, bone metabolism, metabolic functions, and transcription regulation
- It modulates the proliferation and differentiation of both normal and cancer cells
- It presents in vitro antiproliferative and antimetastatic activities on breast, colon, and prostate cancer cells